Graphs are widely used to model complex data in many applications, such as bioinformatics, chemistry, social networks, pattern recognition. A fundamental and critical query primitive is to efficiently search similar structures in a large collection of graphs. This article mainly studies threshold-based graph similarity search with edit distance constraints. Existing solutions to the problem utilize fixed-size overlapping substructures to generate candidates, and thus become susceptible to large vertex degrees and distance thresholds. In this article, we present a partition-based approach to tackle the problem. By dividing data graphs into variable-size non-overlapping partitions, the edit distance constraint is converted to a graph containment constraint for candidate generation. We develop efficient query processing algorithms based on the novel paradigm. Moreover, candidate-pruning techniques and an improved graph edit distance verification algorithm are developed to boost the performance. In addition, a cost-aware graph partitioning method is devised to optimize the index. Extending the partition-based filtering paradigm, we present a solution to the top-k graph similarity search problem, where tailored filtering, look-ahead and computation-sharing strategies are exploited. Using both public real-life and synthetic datasets, extensive experiments demonstrate that our approaches significantly outperform the baseline and its alternatives.